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INTO THE LABS
18 Dec 2009; Howard Boland - 30 Jan 2012

As part of a series of new research engagements stretching back around 3 years, c-lab has entered into two new fields of art-science engagements. The first looks at sensoriality and plants, whilst the other descends upon synthetic biology working with bacteria. The latter, synthetic biology, recently saw its first steps into a university lab exploring techniques towards designing new interactive systems.

Spiral Bacteria © Charles Thomas 2009

The research situates its daily practice in a microbiology laboratory amongst PhD research students and post-docs from the biosciences. As a novel deployment of  art-science practices at the University a fruitful exchange between the two fields emerge from a unique contact point of unfamiliarity. Joint supervision between the arts and sciences is instrumental.

GFP Ecoli - View under Fluorescent Microscope

Synthetic biology is a distinctive field that combines standard laboratory practices  with principles of electronic engineering in order to push genetics towards more advanced discipline through standardisation. One strategy involves the use of biobricks™ or genetic parts that can be pieced together part-by-part, a bottom-up approach, that can introduce a combination of new characteristics in organisms that can perform a network of interaction turning organisms into devices. 

Lab media © c-lab 2009

Preparing media is often akin to following a kitchen recipe however the measurements are more minute and concentrations need precise calculations.

Post autoclave © c-lab 2009

Keeping the media and instruments sterile is essential for controlled development. This research follows standard laboratory requirements which include providing safety forms, autoclaving instructions for technical staff and of course preparing  various media from protocols.

Gel run © c-lab 2009

Running Gel is a technique used to detect and visualize DNA fragments. This technique is also used in extraction of genetic fragments or what synthetic biologists call parts. It is a process that materialises DNA into something visible.

Running gel © c-lab 2009

As the DNA will migratating through agarose gel. The coloured elements help guide how far down the solutions have migrated, but the DNA fragments only becomes visible when stained with flourscent dye (Ethidium Bromide) and viewed under UV light.

E coli GFP © c-lab 2009

Transformation of bacteria by introducing foreign pieces of DNA,  plasmids can be added resulting in bacteria producing new materials. A shock is needed to force the plasmid through the bacterial cell wall, by moving the tube between ice and a waterbath the cell wall becomes disrupted allowing the plasmid to enter.

Transformed E coli on petri dish © c-lab 2009

The transformed bacteria is poured onto plates with antibiotics, those transformed become resistant and will survive - leaving us only with bacteria expressing the new material.

GFP E coli © c-lab 2009

Giving them time to grow overnight, they now carry a new expression which under UV-light gives an irredescent green glow, by continiousley creating a new material - green flourescent protein.

Other References: C-LAB:blog: Britt Wray of Fluxmedia visits C-LAB
C-LAB:blog: Cells alive n' counting
C-LAB:blog: Cellulose from bacteria
C-LAB:blog: Going solid: From Fungi to Mushroom
C-LAB:blog: Growing Magnetospirillium Gryphiswaldense
C-LAB:blog: It's here - the Spring 2012 iGEM library
C-LAB:blog: KatE in a Jar
C-LAB:blog: katE sees red with Red Fluorescent Protein (RFP)
C-LAB:blog: Red Fluorescent Protein
C-LAB:blog: Sludge Bacteria - one drop
C-LAB:blog: Stress light in growth & swarming behaviour
C-LAB:event: ART FROM SYNTHETIC BIOLOGY
C-LAB:event: ART-SCIENCE TALK
C-LAB:event: BIOART FORUM
C-LAB:event: CAGE RATTLING #1: KILL SWITCH
C-LAB:event: DO IT TOGETHER BIO #5: SYNTHETIC BIOLOGY ART
C-LAB:event: GRADUATE SCHOOL LAUNCH
C-LAB:event: INTO THE LABS
C-LAB:event: RE-NEW DIGITAL ARTS FESTIVAL
C-LAB:event: SYNTHETIC BIOLOGY SOCIETY KICK OFF EVENT
C-LAB:event: THE TWO CULTURES: VISUAL ART AND THE SCIENCES C.1800-2011
C-LAB:event: YOUNG SYNTHETIC BIOLOGISTS - YSB 1.0
C-LAB:experiment: Bacteria Compass
C-LAB:project: Bacterial Light Sensor
C-LAB:project: Bacterial World
C-LAB:project: katE - Visualising Stress
C-LAB:project: KatEred
C-LAB:project: Stress-o-stat
C-LAB:project: Sugar Rush
C-LAB:project: Transient Images
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sahil1572 wrote on the 25 Feb 12, 05:07:
thank for wonderful this site i'm going to tell all my classmates.........
 
   
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